Publications from HIS funded research or fellowships


Mawer D, Byrne F, Drake S, Brown C, Prescott A, Warne B, Bousfield R, Skittrall JP, Ramsay I, Somasunderam D, Bevan M, Coslett J, Rao J, Stanley P, Kennedy A, Dobson R, Long S, Obisanya T, Esmailji T, Petridou C, Saeed K, Brechany K, Davis-Blue K, O'Horan H, Wake B, Martin J, Featherstone J, Hall C, Allen J, Johnson G, Hornigold C, Amir N, Henderson K, McClements C, Liew I, Deshpande A, Vink E, Trigg D, Guilfoyle J, Scarborough M, Scarborough C, Wong TN, Walker T, Fawcett N, Morris G, Tomlin K, Grix C, O'Cofaigh E, McCaffrey D, Cooper M, Corbett K, French K, Harper S, Hayward C, Reid M, Whatley V, Winfield J, Hoque S, Kelly L, King I, Bradley A, McCullagh B, Hibberd C, Merron M, McCabe C, Horridge S, Taylor J, Koo S, Elsanousi F, Saunders R, Lim F, Bond A, Stone S, Milligan ID, Mack DJ, Nagar A, West RM, Wilcox MH, Kirby A, Sandoe JA.  Cross-sectional study of the prevalence, causes and management of hospital-onset diarrhoea. J Hosp Infect. 2019 May 8. pii: S0195-6701(19)30192-6. doi:10.1016/j.jhin.2019.05.001.

Rooney CM, Sheppard AE, Clark E, Davies K, Hubbard ATM, Sebra R, Crook DW, Walker AS, Wilcox MH, Chilton CH. Dissemination of multiple carbapenem resistance genes in an in vitro gut model simulating the human colon. The Journal of Antimicrobial Chemotherapy 2019; doi 10.1093/jac/dkz106.


Poller B, Tunbridge A, Hall S, Beadsworth M, Jacobs M, Peters E, Schmid ML, Sykes A, Poran V, Gent N, Evans C, Crook B; High Consequence Infectious Diseases Project Working Group. A unified personal protective equipment ensemble for clinical response to possible high consequence infectious diseases: A consensus document on behalf of the HCID programme. J Infect. 2018 Dec;77(6):496-502 doi: 10.1016/j.jinf.2018.08.016.

Bevan ER., McNally A., Thomas CM., Piddock LJV, Hawkey, P. M. Acquisition and Loss of CTX-M-Producing and Non-Producing Escherichia coli in the Fecal Microbiome of Travelers to South Asia. mBio Nov/Dec 2018:9(6):e02408-18. doi: 10.1128/mBio.02408-18.

Kümin M, Harper CM, Reed M, Bremner S, Perry N, Scarborough M. Reducing Implant Infection in Orthopaedics (RIIiO): a pilot study for a randomised controlled trial comparing the influence of forced air versus resistive fabric warming technologies on postoperative infection rates following orthopaedic implant surgery in adults. Trials. 2018 Nov 19;19(1):640. doi: 10.1186/s13063-018-3011-y.

Ledwoch K, Dancer SJ, Otter JA, Kerr K, Roposte D, Rushton L, Weiser R, Mahenthiralingam E, Muir DD, Maillard JY. Beware biofilm! Dry biofilms containing bacterial pathogens on multiple healthcare surfaces; a multi-centre study. J Hosp Infect. 2018 Nov;100(3):e47-e56. doi: 10.1016/j.jhin.2018.06.028. 

Wesgate R, Robertson A, Barrell M, Maillard JY. Impact of test protocols and material binding on antimicrobial wipes efficacy. J Hosp Infect. 2018 Sep 28.pii: S0195-6701(18)30507-3. doi: 10.1016/j.jhin.2018.09.016.

Poller B, Hall S, Bailey C, Gregory S, Clark R, Roberts P, Tunbridge A, Poran V, Crook B, Evans C. 'VIOLET': a fluorescence-based simulation exercise for training healthcare workers in the use of personal protective equipment. J Hosp Infect. 2018 Jun;99(2):229-235. doi: 10.1016/j.jhin.2018.01.021. 

Hall S, Poller B, Bailey C, Gregory S, Clark R, Roberts P, Tunbridge A, Poran V, Evans C, Crook B. Use of ultraviolet-fluorescence-based simulation in evaluation of personal protective equipment worn for first assessment and care of a patient with suspected high-consequence infectious disease. J Hosp Infect. 2018 Jun;99(2):218-228. doi: 10.1016/j.jhin.2018.01.002.



Toleman MS, Watkins ER, Williams T, Blane B, Sadler B, Harrison EM, Coll F, Parkhill J, Nazareth B, Brown NM, Peacock SJ. Investigation of a Cluster of
Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Transmission in a Community Setting. Clin Infect Dis. 2017 Nov 29;65(12):2069-2077. doi:10.1093/cid/cix539. 

Coll F, Harrison EM, Toleman MS, Reuter S, Raven KE, Blane B, Palmer B, Kappeler ARM, Brown NM, Török ME, Parkhill J, Peacock SJ. Longitudinal genomic
surveillance of MRSA in the UK reveals transmission patterns in hospitals and the community. Sci Transl Med. 2017 Oct 25;9(413). pii: eaak9745. doi:

Hutchins CF, Moore G, Thompson KA, Webb J, Walker JT. Contamination of hospital tap water: the survival and persistence of Pseudomonas aeruginosa on conventional and 'antimicrobial' outlet fittings. J Hosp Infect. 2017 Oct;97(2):156-161. doi: 10.1016/j.jhin.2017.06.005.

Hogan S, Zapotoczna M, Stevens NT, Humphreys H, O'Gara JP, O'Neill E. Potential use of targeted enzymatic agents in the treatment of Staphylococcus
aureus biofilm-related infections. J Hosp Infect. 2017 Jun;96(2):177-182. doi:10.1016/j.jhin.2017.02.008.

Zapotoczna M, Forde É, Hogan S, Humphreys H, O'Gara JP, Fitzgerald-Hughes D, Devocelle M, O'Neill E. Eradication of Staphylococcus aureus Biofilm Infections Using Synthetic Antimicrobial Peptides. J Infect Dis. 2017 Mar 15;215(6):975-983. doi: 10.1093/infdis/jix062.




van Kleef E, Deeny SR, Jit M, Cookson B, Goldenberg SD, Edmunds WJ, Robotham JV. The projected effectiveness of Clostridium difficile vaccination as part of an integrated infection control strategy. Vaccine. 2016 Nov 4;34(46):5562-5570. doi: 10.1016/j.vaccine.2016.09.046. 

Harrison EM, Ludden C, Brodrick HJ, Blane B, Brennan G, Morris D, Coll F, Reuter S, Brown NM, Holmes MA, O'Connell B, Parkhill J, Török ME, Cormican M,
Peacock SJ. Transmission of methicillin-resistant Staphylococcus aureus in long-term care facilities and their related healthcare networks. Genome Med. 2016 Oct 3;8(1):102

Mahida N, Boswell T. Control of carbapenemase-producing organsims: complexities of 'real-life' and what is the best method of terminal room disinfection? J Hosp Infect. 2016 Nov ;94(3):254-255. doi: 10.1016/j.jhin.2016.07.019.

Hogan S, Zapotoczna M, Stevens NT, Humphreys H, O'Gara JP, O'Neill E. Eradication of Staphylococcus aureus Catheter-Related Biofilm Infections Using
ML:8 and Citrox. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5968-75. doi:10.1128/AAC.00910-16. 

Mahida N, Boswell T. Non-slip socks: a potential reservoir for transmitting multidrug-resistant organisms in hospitals? J Hosp Infect. 2016 Nov;94(3):273-275. doi: 10.1016/j.jhin.2016.06.018. 

Joseph A, Mahida N. Antimicrobial stewardship in secondary care: what are we  trying to achieve? J Hosp Infect. 2016 Aug;93(4):392-4. doi: 10.1016/j.jhin.2016.06.003. 

Mahida N, Clarke M, Jabeen F. Management of an influenza A outbreak on an acute internal medicine ward. J Hosp Infect. 2016 Oct;94(2):154-5. doi:10.1016/j.jhin.2016.06.004. 

Toleman MS, Reuter S, Coll F, Harrison EM, Peacock SJ. Local Persistence of Novel MRSA Lineage after Hospital Ward Outbreak, Cambridge, UK, 2011-2013. Emerg Infect Dis. 2016 Sep;22(9):1658-9. doi: 10.3201/eid2209.151100.

Wesgate R, Rauwel G, Criquelion J, Maillard JY. Impact of standard test protocols on sporicidal efficacy. J Hosp Infect. 2016 Jul;93(3):256-62. doi:10.1016/j.jhin.2016.03.018. 

Toleman MS, Reuter S, Coll F, Harrison EM, Blane B, Brown NM, Török ME, Parkhill J, Peacock SJ. Systematic Surveillance Detects Multiple Silent
Introductions and Household Transmission of Methicillin-Resistant Staphylococcus aureus USA300 in the East of England. J Infect Dis. 2016 Aug 1;214(3):447-53. doi: 10.1093/infdis/jiw166.

Beal A, Mahida N, Staniforth K, Vaughan N, Clarke M, Boswell T. First UK trial of Xenex PX-UV, an automated ultraviolet room decontamination device in a clinical haematology and bone marrow transplantation unit. J Hosp Infect. 2016 Jun;93(2):164-8. doi: 10.1016/j.jhin.2016.03.016.

Workman DG,  Hunter M , Dover LG, Tétard D. Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents. Journal of Inorganic Biochemistry 2016 Apr; 160: 49-58. doi: 10.1016/j.jinorgbio.2016.04.018.

Hogan S, Zapotoczna M, Stevens NT, Humphreys H, O'Gara JP, O'Neill E. In Vitro Approach for Identification of the Most Effective Agents for Antimicrobial  Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2923-31. doi: 10.1128/AAC.02885-15.

Reuter S, Török ME, Holden MT, Reynolds R, Raven KE, Blane B, Donker T, Bentley SD, Aanensen DM, Grundmann H, Feil EJ, Spratt BG, Parkhill J, Peacock SJ. Building a genomic framework for prospective MRSA surveillance in the United Kingdom and the Republic of Ireland. Genome Res. 2016 Feb;26(2):263-70. doi: 10.1101/gr.196709.115. . Erratum in: Genome Res. 2017 Sep;27(9):1622.

Yiannakis EP, Boswell TC. Systematic review of outbreaks of Pneumocystis jirovecii pneumonia: evidence that P. jirovecii is a transmissible organism and the implications for healthcare infection control. J Hosp Infect. 2016 May;93(1):1-8. doi: 10.1016/j.jhin.2016.01.01


Hogan S, Stevens NT, Humphreys H, O'Gara JP, O'Neill E. Current and future approaches to the prevention and treatment of staphylococcal medical device-related infections. Curr Pharm Des. 2015;21(1):100-13. 

Workman DG, Tsatsanis A, Lewis FW, Boyle JP, Mousadoust M, Hettiarachchi NT, Hunter M, Peers CS, Tétard D, Duce JA. Protection from neurodegeneration in the 6-hydroxydopamine (6-OHDA) model of Parkinson's with novel 1-hydroxypyridin-2-one metal chelators. Metallomics (2015);7(15): 867-76. doi: 10.1039/C4MT00326H


van Kleef E, Green N, Goldenberg SD, Robotham JV, Cookson B, Jit M, Edmunds WJ, Deeny SR. Excess length of stay and mortality due to Clostridium difficile infection: a multi-state modelling approach. J Hosp Infect. 2014 Dec;88(4):213-7. doi: 10.1016/j.jhin.2014.08.008. 

Stolbrink M, McGowan L, Saman H, Nguyen T, Knightly R, Sharpe J, Reilly H, Jones S, Turner AM. The Early Mobility Bundle: a simple enhancement of therapy which may reduce incidence of hospital-acquired pneumonia and length of hospital  stay. J Hosp Infect. 2014 Sep;88(1):34-9. doi: 10.1016/j.jhin.2014.05.006. 

van Kleef E, Gasparrini A, Guy R, Cookson B, Hope R, Jit M, Robotham JV, Deeny SR, Edmunds WJ. Nosocomial transmission of C. difficile in English
hospitals from patients with symptomatic infection. PLoS One. 2014 Jun 16;9(6):e99860. doi: 10.1371/journal.pone.0099860.

Holling N, Dedi C, Jones CE, Hawthorne JA, Hanlon GW, Salvage JP, Patel BA, Barnes LM, Jones BV. Evaluation of environmental scanning electron microscopy for analysis of Proteus mirabilis crystalline biofilms in situ on urinary catheters.  FEMS Microbiol Lett. 2014 Jun;355(1):20-7. doi: 10.1111/1574-6968.12451. 

Holling N, Lednor D, Tsang S, Bissell A, Campbell L, Nzakizwanayo J, Dedi C, Hawthorne JA, Hanlon G, Ogilvie LA, Salvage JP, Patel BA, Barnes LM, Jones BV.
Elucidating the genetic basis of crystalline biofilm formation in Proteus mirabilis. Infect Immun. 2014 Apr;82(4):1616-26. doi: 10.1128/IAI.01652-13. 



van Kleef E, Robotham JV, Jit M, Deeny SR, Edmunds WJ. Modelling the transmission of healthcare associated infections: a systematic review. BMC Infect
Dis. 2013 Jun 28;13:294. doi: 10.1186/1471-2334-13-294.